Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer
نویسندگان
چکیده
منابع مشابه
Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer.
By fitting dynamic contrast-enhanced MRI data to an appropriate pharmacokinetic model, quantitative physiological parameters can be estimated. In this study, we compare four different models by applying four statistical measures to assess their ability to describe dynamic contrast-enhanced MRI data obtained in 28 human breast cancer patient sets: the chi-square test (χ(2)), Durbin-Watson statis...
متن کاملDynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI.
The passage of a vascular-injected paramagnetic contrast reagent (CR) bolus through a region-of-interest affects tissue (1)H(2)O relaxation and thus MR image intensity. For longitudinal relaxation [R(1) identical with (T(1))(-1)], the CR must have transient molecular interactions with water. Because the CR and water molecules are never uniformly distributed in the histological-scale tissue comp...
متن کاملDynamic Contrast Enhanced MRI of Carotid Plaque: Comparison of Pharmacokinetic Models
Objective The rupture of an atherosclerotic plaque is a major cause of ischemic events, such as stroke and myocardial infarction. Plaque vulnerability has been linked to the formation of angiogenic microvessels within the plaque. It has been shown that dynamic-contrast enhanced MRI (DCE-MRI) allows the detection and quantification of this neovascularisation. Pharmacokinetic models are used to d...
متن کاملComparison of choline and pharmacokinetic parameters in breast cancer measured by MR spectroscopic imaging and dynamic contrast enhanced MRI.
Although an MRI scanner is a single stand-alone modality, different acquisition techniques may be applied to collect structural and functional information, including vascular or angiogenic properties measured by dynamic contrast enhanced MRI (DCE-MRI) and Choline (Cho) metabolism measured by proton MR spectroscopy imaging (MRSI). They may provide complementary information for a better character...
متن کاملAutomatic Prostate Cancer Segmentation Using Kinetic Analysis in Dynamic Contrast-Enhanced MRI
Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides functional information on the microcirculation in tissues by analyzing the enhancement kinetics which can be used as biomarkers for prostate lesions detection and characterization.Objective: The purpose of this study is to investigate spatiotemporal patterns of tumors by extracting semi-quantitative as well as w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2011
ISSN: 0740-3194
DOI: 10.1002/mrm.23205